Mechanism of foetal wastage following immunoneutralization of riboflavin carrier protein in the pregnant rat: disturbances in flavin coenzyme levels
- 3 December 1984
- journal article
- Published by Wiley in FEBS Letters
- Vol. 178 (1) , 87-91
- https://doi.org/10.1016/0014-5793(84)81246-6
Abstract
Immunoneutralization of maternal RCP results in a >90% decrease in the content and the incorporation of [2‐14C]riboflavin into embryonic FAD as well as a percentage redistribution of both embryonic FMN and riboflavin. This is unaccompanied by any discernible changes in flavin distribution pattern in the maternal liver. Embryonic α‐glycerophosphate dehydrogenase and NADPH‐cytochrome c reductase register significant decreases in activities in the RCP antiserum‐treated rats. These alterations readily explain the arrest of foetal growth culminating in pregnancy termination in the antiserum‐treated animals.Keywords
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