In vivo Effect of a Fluoridating Varnish with Various Fluoride Contents on Human Enamel

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Abstract
The purpose of this in vivo study was to compare the fluoride acquisition on (Fon) as well as in (Fin) enamel after a single application of polyurethane varnishes. The varnishes investigated were all on the same polyurethane basis but contained either 0, 0.05, 0.1 or 0.7 wt% fluoride. The varnishes were removed after an application period of 24 h. A new technique for in vivo experimentations was developed using frame prostheses with slots to hold the experimental human enamel specimens. 11 participants carried 52 enamel specimens in frames for 1 week. Fon and Fin measurements were done after the experiment. The acquired amount of fluoride as Fon after 1 week was such that varnish 0.7% > varnish 0.1% ≃ varnish 0.05% ≃ varnish 0% ≃ control. The acquired fluoride as Fin showed the same ranking. From a clinical point of view this study shows that it is not interesting to consider varnishes with a content of 0.1 wt% F–– or lower for caries prevention, because 6 days after removal both Fon and Fin are hardly different from unfluoridated conditions.

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