Effect of insulin on glucose metabolism in adipocytes from virgin and late-pregnant rats
- 1 December 1984
- journal article
- research article
- Published by Portland Press Ltd. in Biochemical Journal
- Vol. 224 (2) , 685-688
- https://doi.org/10.1042/bj2240685
Abstract
Under basal conditions (zero insulin), paraovarian adipocytes from 19-day-pregnant rats exhibited the same rates of [U-14C]glucose conversion into CO2 and total lipids as did those from age-matched virgin rats. The dose-response curves for insulin stimulation of glucose metabolism were similar in both groups: maximal response (+100% over basal values) and high sensitivity (half-maximal effect at 0.05 nM-insulin). The present results suggest that the insulin resistance in vivo that occurs during late pregnancy may involve circulating factors lost in vitro.This publication has 31 references indexed in Scilit:
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