The effects of 3′- and 4′-substituents on the ionisation constants of biphenyl-4-carboxylic acid and 4-aminobiphenyl
- 1 January 1966
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society C: Organic
- p. 831-836
- https://doi.org/10.1039/j39660000831
Abstract
Measurement of the ionisation constants for a range of 3′- and 4′-substituted biphenyl-4-carboxylic acids and 4-aminobiphenyls has confirmed the earlier conclusion that the electronic effects of substituents are transmitted to the 4-position, but in diminished magnitude compared with the analogous benzene systems. Inductive effects alone do not entirely account for the relative ionisation constants of the 3′-substituted acids, and this suggests that the mesomeric effect of the 3′-substituent should not be discounted. The relationship between the pKa values for the 3′- and 4′-substituted acids and the Hammett substituent constants is discussed.Keywords
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