Genetic variance of laboratory outbred Swiss mice

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Abstract
The extent of allelic variation was estimated at 46 structural gene loci within 3 major colonies of Swiss mice [Mus musculus] and between inbred derivative strains. The colonies retained nearly the same amount and type of variation found in natural murine or human populations despite laboratory propagation for > 50 yr (175 generations). The population genetic structures of the Swiss mouse colonies were comparable to an island population in which random fixation, and not inbreeding or population bottlenecks, is apparently responsible for slight losses in genetic variance.