Demonstration of inter- and intraspecies differences in serotonin binding sites by antibodies from an autistic child.

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Abstract
Serotonin [5-hydroxytryptamine] (5-HT) binding sites from bovine and rat cerebral cortex membranes share pharmacological properties that allow both to be subclassified by the same criteria. [3H]5-HT binding sites from human cortex also possess pharmacological properties that follow the same subclassification scheme as for bovine and rat cortex. Solubilized 5-HT1 and 5-HT3 sites from all 3 species have an s20,w [sedimentation coefficient] value of 3.4. Despite these similar pharmacological and physical characteristics, antigenic differences between receptor types and species can be demonstrated. Human 5-HT1A sites can be distinguished from human 5-HT1B, 5-HT2 and 5-HT3 sites and from equivalent sites in rat and bovine cortex. The anti-human 5-HT1A antibodies were discovered in the blood of an autistic child and may have clinical or etiologic significance for this disorder.

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