Irradiated Larval Vaccination of Ponies against Strongylus vulgaris

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Abstract
Nonimmune pony foals 9-12 mo. of age were vaccinated with 3rd-stage S. vulgaris larvae (L3) irradiated with 70, 100 or 130 kR of .gamma. radiation. Ponies receiving per os inoculations of L3 irradiated with 70 or 100 kR were protected from the clinical disease and lesions associated with challenge infections of 4300 L3, when compared to nonvaccinated controls. The numbers of worms from the challenging population recovered from successfully vaccinated animals were significantly lower than from nonvaccinated controls. The degree of resistance that develops in individuals can be semiquantitated based on clinical and pathological responses.