Correlation of degradative rates of proteins with a parameter calculated from amino acid composition and subunit size.
- 1 September 1976
- journal article
- research article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 73 (9) , 3093-3097
- https://doi.org/10.1073/pnas.73.9.3093
Abstract
A parameter is developed which relates the amino acid composition and subunit size of a protein to the degradative rate in vivo. This parameter was calculated for 11 rat liver proteins; a plot vs. the half-lives of these proteins is linear and has a coefficient of -0.96. Evidence suggests that the density of excess acidic amino acids on the surface of the protein is the most important factor in determining differential turnover.This publication has 51 references indexed in Scilit:
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