Interleukin-21: a modulator of lymphoid proliferation, apoptosis and differentiation
Top Cited Papers
- 1 September 2005
- journal article
- review article
- Published by Springer Nature in Nature Reviews Immunology
- Vol. 5 (9) , 688-698
- https://doi.org/10.1038/nri1688
Abstract
The interleukin-21 (IL-21)-IL-21-receptor system was discovered in 2000. It was immediately of great interest because of the homology of IL-21 to IL-2, IL-4 and IL-15, and of the IL-21-receptor subunit IL-21R to the beta-subunit of the IL-2 receptor, and because the IL-21 receptor also contains the common cytokine-receptor gamma-chain, the protein that is mutated in X-linked severe combined immunodeficiency. As we discuss, IL-21 has pleiotropic actions, from augmenting the proliferation of T cells and driving the differentiation of B cells into memory cells and terminally differentiated plasma cells to augmenting the activity of natural killer cells. Moreover, it has antitumour activity and might have a role in the development of autoimmunity, so these findings have implications for the treatment of cancer and autoimmune diseases.Keywords
This publication has 93 references indexed in Scilit:
- Program Death-1 Engagement Upon TCR Activation Has Distinct Effects on Costimulation and Cytokine-Driven Proliferation: Attenuation of ICOS, IL-4, and IL-21, But Not CD28, IL-7, and IL-15 ResponsesThe Journal of Immunology, 2003
- IL-21 Up-Regulates the Expression of Genes Associated with Innate Immunity and Th1 ResponseThe Journal of Immunology, 2002
- The Common γ Chain (γc) Is a Required Signaling Component of the IL-21 Receptor and Supports IL-21-Induced Cell Proliferation via JAK3Biochemistry, 2002
- Cytokines and immunodeficiency diseasesNature Reviews Immunology, 2001
- Cutting Edge: The Common γ-Chain Is an Indispensable Subunit of the IL-21 Receptor ComplexThe Journal of Immunology, 2001
- Interleukin 21 and its receptor are involved in NK cell expansion and regulation of lymphocyte functionNature, 2000
- Cloning of a type I cytokine receptor most related to the IL-2 receptor β chainProceedings of the National Academy of Sciences, 2000
- Mutation of Jak3 in a Patient with SCID: Essential Role of Jak3 in Lymphoid DevelopmentScience, 1995
- Mutations of Jak-3 gene in patients with autosomal severe combined immune deficiency (SCID)Nature, 1995
- Interleukin-2 receptor γ chain mutation results in X-linked severe combined immunodeficiency in humansCell, 1993