Long term treatment of chronic hepatitis C with interferon alfa-2b: disappearance of HCV-RNA in a pilot study of eight haemophilia patients.
Open Access
- 1 January 1993
- Vol. 34 (2 Suppl) , S124-S125
- https://doi.org/10.1136/gut.34.2_suppl.s124
Abstract
This pilot study was designed to establish the effect of long term alpha interferon treatment in haemophilia patients with chronic hepatitis C. Overall, three of eight (37.5%) patients showed a complete response, three of eight (37.5%) a transient response, and two of eight (25.0%) no response. HCV-RNA detection by polymerase chain reaction was more sensitive in detecting relapse than alanine amino-transferase (ALT) activity measurement, suggesting that current interferon schedules based on the ALT response should be re-evaluated critically.Keywords
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