Soft Bones, Hard Facts and Calcitonin Therapy

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Abstract
Calcitonin is a polypeptide — probably a hormone — isolated from the thyroid gland or ultimobranchial body of a wide variety of species ranging from the Pacific salmon to man. In all examples that have been studied to date, the peptide contains 32 amino acid residues with a characteristic amino terminal disulfide ring and prolinamide at the carboxyl terminus, but with many differences in individual amino acids along the mid-portion of the chain.1 , 2 The most widely recognized biologic actions of calcitonin are its hypocalcemic and hypophosphatemic effects.1 , 3 These appear to result from a direct, rapid and transient inhibitory action on . . .

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