Metabolic responsiveness of spontaneously hypertensive rat to isoproterenol

Publisher Website
Google Scholar
Abstract
The metabolic responsiveness of spontaneously hypertensive (SH) and Wistar-Kyoto (WKY) normotensive rats to administration of the .beta.-adrenergic agonist, isoproterenol, was assessed by changes in tail-skin temperature, heart rate and plasma glucose concentration after administration of graded doses of isoproterenol. The increases in mean tail-skin temperature accompanying administration of isoproterenol at doses of 5, 10 and 40 .mu.g/kg s.c. were significantly (P < 0.05) greater for SH than for WKY rats. Resting colonic temperatures of the SH rats were significantly (P < 0.01) higher than those of the WKY normotensive rats. Mean maximal heart rates of unanesthetized SH rats after administration of isoproterenol at doses of 5, 10 and 20 .mu.g/kg s.c. increased to levels significantly (P < 0.05-0.01) higher than those of WKY normotensive rats. Resting heart rates were similar in both groups. Increases in plasma glucose concentration after administration of isoproterenol at doses of 5, 10 and 20 .mu.g/kg s.c. were significantly (P < 0.05) greater in the SH rats compared with the WKY rats. The SH rat apparently has a significantly greater metabolic responsiveness to .beta.-adrenergic stimulation, as assessed by 3 separate tests of .beta.-adrenergic function, than does the WKY rat.