Effects of ADP and ATP on Bovine Fibrinogen‐ and Ristocetin‐Induced Platelet Aggregation in Glanzmann's Thrombasthenia
- 1 November 1975
- journal article
- Published by Wiley in British Journal of Haematology
- Vol. 31 (3) , 343-347
- https://doi.org/10.1111/j.1365-2141.1975.tb00865.x
Abstract
Summary.: With thrombasthenic platelets, aggregation induced by ristocetin (R) and bovine fibrinogen (BF) is reversible, provided ATP is not added to the system. ADP inhibits BF and R induced aggregation, and when added after the onset of aggregation causes rapid disaggregation. ATP prevents these inhibitory and disaggregation effects of ADP. A mechanism is suggested whereby co‐operative effects occur between receptors in the membranes of thrombasthenic platelets.Keywords
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