Serum Alpha-Tocopherol in Pregnancies with Normal or Pathological Outcomes

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Abstract
Results indicate that, in comparison with normal pregnancies, in pregnancies leading to abortions, stillbirths, and congenitally malformed infants, maternal alpha-tocopherol differs both as to serum levels and as to rates of increase during gestation. In women aborting or giving birth to malformed infants, decreases in serum alpha-tocopherol levels were noted in the second trimester. In pregnancies ending in stillbirths, the increases in alpha-tocopherol levels were slower and significantly lower than in normal pregnancies. Because of the limited number of observations no causal relationships were proposed but the hypothesis of a vitamin basis for congenital deformities appears worth testing.

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