Isolation and Some Characteristics of Urokinase Inhibitors Isolated from Pig Leucocytes
- 1 January 1981
- journal article
- research article
- Published by S. Karger AG in Pathophysiology of Haemostasis and Thrombosis
- Vol. 10 (4) , 215-232
- https://doi.org/10.1159/000214406
Abstract
Two inhibitors of urokinase were isolated from the extracts of the nuclei of peripheral pig leucocytes, by ion exchange chromatography and by gel filtration on Sephadex G-100 and G-150. Only the inhibitor with the higher molecular weight was isolated in the homogenous form, in a single polypeptide chain with molecular weight of 68,000, designated Inhibitor-3. This inhibitor has an isoelectric point from 4.4 to 4.5 and is stable in buffer solutions from pH 3 to 8, and belongs to the type of so-called fast reacting inhibitors.This publication has 2 references indexed in Scilit:
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- Identification and Some Properties of a New Fast‐Reacting Plasmin Inhibitor in Human PlasmaEuropean Journal of Biochemistry, 1976