Effect of Vitamin A on Palate Hydration in Mouse Embryos

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Abstract
A group of pregnant A/Jax mice received 10,000 units of vitamin A in 0.2 ml of oil administered by mouth on 11 1/2 and 12 1/2 day of gestation. The control group received 0.2 ml of oil at the same times. All mice were killed on 15 1/2 day of gestation. Palatal shelves of all fetuses were dissected, weighted, desiccated and weighted again, to measure the amount of water removed. A significant increase of (1) the wet weight of palatine shelves, and (2) the amount of water lost during desiccation was observed in the offspring derived from vitamin-A-treated animals. The significance of these results seems to be further amplified by the fact that the total body size of experimental fetuses was found to be smaller than that of control animals.

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