Foreign Body Tumorigenesis: Timing and Location of Preneoplastic Events2

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Abstract
Plastic or glass coverslips were inserted subcutaneously in CBA/H or CBA/H-T6 mice and their hybrids. After various intervals, segments of implants and surrounding tissue capsules that resulted from foreign body reaction were transplanted to recipient animals. Thesewere distinguishable from original implant carriers on the basis of the T6-marker chromosome. Tumors in multiple recipients (having received segments from the same implant) indicated presence of preneoplastic cells in the original implant carrier before transplantation. Such tumors were identical with regard to clone-specific chromosomal deviations, time of tumor appearance, histopathology, and degree of malignancy (“homologous tumors”). They differed from tumors that had developed from other implants. This experimental system showed that the first preneoplastic parent cells, being endowed with the specific characteristics of the later tumors, appeared at the foreign body reaction site within 1 month after initial implantation of the foreign body. At least two classes of preneoplastic parent cells seemed to exist which differed in duration of preneoplastic latency. Which class predominated in foreign body reactions was to some extent under the influence of sex. Tumor development from parent cells of either class could be accelerated experimentally by transplantation of the whole unopened film/capsule complex 4 to 5 months after implantation. A preneoplastic parent cell seemed to expand into a clone shortly after it appeared at the foreign body site. Clonal progeny was demonstrated at first in the capsular and the extracapsular tissues of a foreign body reaction, and later within the capsule tissue and directly on the implant surface.

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