RECOGNITION OF MARROW ELEMENTS BY NATURAL KILLER CELLS: ARE NK CELLS INVOLVED IN HAEMOPOIETC REGULATION?
- 1 January 1983
- journal article
- Published by Wiley in British Journal of Haematology
- Vol. 53 (1) , 161-164
- https://doi.org/10.1111/j.1365-2141.1983.tb01998.x
Abstract
NK cells from young normal mice are cytolytic in vitro for a virus-induced tumour cell line, YAC-1. Cytotoxicity is inhibited by the addition of unlabelled homologous YAC-1 cells and by regenerating bone marrow cells from the spleens of lethally irradiated, bone-marrow-grafted mice. Quiescent marrow from syngeneic and allogeneic mice produces little or no competition. This suggests that NK cells recognize, and may regulate, marrow progenitor cells.Keywords
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