Inhibition of metabolic cooperation by the anticonvulsants, diphenylhydantoin and phenobarbital
- 1 January 1985
- journal article
- research article
- Published by Wiley in Teratogenesis, Carcinogenesis, and Mutagenesis
- Vol. 5 (6) , 379-391
- https://doi.org/10.1002/tcm.1770050602
Abstract
High densities of 6‐thioguanine‐sensitive Chinese hamster V79 cells reduce the recovery of co‐cultured 6‐thioguanine‐resistant cells through a form of intercellular communication (metabolic cooperation). Diphenylhydantoin and phenobarbital, suspected human and animal teratogens and tumor promoters, were able to inhibit intercellular communication at noncytotoxic doses. A potentiation was observed when a mixture of the two chemicals was used.Keywords
This publication has 63 references indexed in Scilit:
- Discordant Expression of Fetal Hydantoin Syndrome in Heteropaternal Dizygotic TwinsNew England Journal of Medicine, 1982
- Zur Teratogenität von AntikonvulsivaDeutsche Medizinische Wochenschrift (1946), 1980
- Membrane and other Biochemical Effects of the Phorbol Esters and their Relevance to Tumor PromotionPublished by Springer Nature ,1980
- Handbook of TeratologyPublished by Springer Nature ,1977
- Risks to the offspring of women treated with hydantoin anticonvulsants, with emphasis on the fetal hydantoin syndromeThe Journal of Pediatrics, 1976
- The fetal hydantoin syndromeThe Journal of Pediatrics, 1975
- Infants Exposed in Utero to Antiepileptic DrugsAmerican Journal of Diseases of Children, 1974
- Diphenylhydantoin and Selected Congenital MalformationsNew England Journal of Medicine, 1973
- Diphenylhydantoin teratogenicity in ratsToxicology and Applied Pharmacology, 1972
- Relation of dosage and time of administration of diphenylhydantoin to its teratogenic effect in miceTeratology, 1969