Altered Vascular Permeability in Ocular Inflammatory Disease

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Abstract
Three experimental models were utilized to demonstrate the effect of structural alteration following inflammation on ocular vascular permeability and its role in predisposition to inflammatory recurrence. The models studied are (1) the conjunctival immunization model, (2) the intravitreal immunogenic reaction, and (3) penetrating keratoplasty. Each model showed enhanced vascular permeability to human serum albumin labeled with iodine 125 (HSA 125I) during active inflammation and intravascular accumulation of radioactive red blood cells. However, when inflammation had become inactive, vascular permeability was enhanced only for HSA 125I. These findings would indicate a permanent "hole" in the inflamed eye's vascular system which would readily predispose to recurrence of inflammation.

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