Experimental Obstructive Hydronephrosis in Newborn Rats. VI. Long-Term Effects on Glomerular Filtration and Distribution

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Abstract
Partial obstruction of 1 ureter was created in newborn rats and its effects were studied after the rats matured. The obstructed pelvis was found to be considerably enlarged. The parenchymal weight was 19% lower and the whole kidney glomerular filtration rate was 43% lower than on the contralateral intact side (P < 0.001); however, these figures probably include a compensatory increase on the intact side. In the central part of the cortex, the glomerular filtration rate/mg cortex was 21% lower in the hydronephrotic kidney (P < 0.02), but there was no intracortical redistribution. The glomerular density in this region was 24% higher on the hydronephrotic side (P < 0.001), because the glomeruli were crammed together in the distended cortex. No redistribution of glomeruli was found. In this model, partially obstructive uropathy was found to cause only a moderate depression, but no redistribution, of the filtration.