Formation of biologically active 13,14-dihydro-prostaglandin E1 during intravenous infusion of prostaglandin E1 in newborns with ductus arteriosus-dependent congenital heart disease.
Open Access
- 1 March 1992
- journal article
- Published by Wiley
- Vol. 33 (3) , 323-325
- https://doi.org/10.1111/j.1365-2125.1992.tb04044.x
Abstract
Plasma concentrations of prostaglandin (PG) E1 (12-150, median 25 pg ml- 1) and 13,14-dihydro-PGE1 (3-62, median 45.5 pg ml-1) were measured by gas chromatography-mass spectrometry in eight newborns with ductus arteriosus-dependent congenital heart disease during continuous intravenous infusion of PGE1. Formation of 13,14-dihydro-PGE1 was demonstrated for the first time in neonates. Since 13,14-dihydro-PGE1 has similar biological activities as the parent compound PGE1, pharmacological effects during PGE1 infusion are most likely related to both PGE1 and the generation and action of 13,14-dihydro-PGE1.Keywords
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