Identification of the Essential Regions for LukS- and HγII-Specific Functions of Staphylococcal Leukocidin andγ-Hemolysin
- 1 January 1995
- journal article
- Published by Oxford University Press (OUP) in Bioscience, Biotechnology, and Biochemistry
- Vol. 59 (8) , 1603-1604
- https://doi.org/10.1271/bbb.59.1603
Abstract
Staphylococcal leukocidin and gamma-hemolysin consist of LukF and LukS for leudocidin and LukF and H gamma II for gamma-hemolysin. To identify the pivotal domain(s) of LukS and H gamma II responsible for their specific cytolytic activities, a series of chimeric genes (lukS/hlg2) were constructed and expressed in Escherichia coli. The results indicate that the C-terminal 24-residue and the N-terminal 57-residue segments of LukS and H gamma II, respectively, are the essential regions for the LukS and H gamma II functions.Keywords
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