Normal CSF Hypocretin-1 (Orexin A) Levels in Dementia with Lewy Bodies Associated with Excessive Daytime Sleepiness
- 1 September 2004
- journal article
- research article
- Published by S. Karger AG in European Neurology
- Vol. 52 (2) , 73-76
- https://doi.org/10.1159/000079749
Abstract
Excessive daytime sleepiness, hallucinations and REM sleep behavior disorder are symptoms reported in both dementia with Lewy bodies (DLB) and narcolepsy. Considering the demonstration of low hypocretin-1/orexin A levels in the cerebrospinal fluid (CSF) of most patients with narcolepsy, we hypothesized the presence of a deficient hypocretinergic transmission in DLB. Hypocretin-1 was tested in the CSF of 10 DLB patients. Levels were found to be in the normal range (mean 521 pg/ml, range 382–667) when compared to controls (n = 20, mean 497 pg/ml, range 350–603) and Alzheimer’s disease patients (n = 7, mean 474 pg/ml, range 333–564). In DLB, excessive daytime sleepiness, hallucinations and REM sleep behavior may occur in the absence of a detectable hypocretin deficiency.Keywords
This publication has 10 references indexed in Scilit:
- CSF hypocretin-1 levels in narcolepsy, Kleine-Levin syndrome, and other hypersomnias and neurological conditionsJournal of Neurology, Neurosurgery & Psychiatry, 2003
- Low levels of ventricular CSF orexin/hypocretin in advanced PDNeurology, 2003
- Orchestrating sleep-wake functions in the brainNature Medicine, 2003
- Hypocretin-1 (Orexin-A) Levels in Human Lumbar CSF in Different Age Groups: Infants to Elderly PersonsSleep, 2002
- Normal hypocretin-1 levels in Parkinson’s disease patients with excessive daytime sleepinessNeurology, 2002
- CSF hypocretin/orexin levels in narcolepsy and other neurological conditionsNeurology, 2001
- Hypocretin (orexin) deficiency in human narcolepsyThe Lancet, 2000
- Report of the second dementia with Lewy body international workshopNeurology, 1999
- Consensus guidelines for the clinical and pathologic diagnosis of dementia with Lewy bodies (DLB)Neurology, 1996