COMPARISON OF NEUROMUSCULAR EFFECTS AND ACUTE TOXICITY OF SOME AMINOGLYCOSIDE ANTIBIOTICS

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  • 1 January 1978
    • journal article
    • research article
    • Vol. 233  (2) , 343-350
Abstract
The correlation between acute toxicity and the effects occurring at the neuromuscular junction level of some aminoglycoside antibiotics was investigated. Netilmicin (Sch [Schering] 20569), sisomicin, gentamicin and kanamycin were administered i.v. in the rat, and neuromuscular blocking activity (sciatic-gastrocnemius preparation) and acute toxicity evaluation were studied. Neuromuscular blocking effects are well correlated to acute toxicity data for all test-antibiotics. A sequence of relative potency follows: netilmicin = sisomicin > gentamicin > kanamycin. Both respiratory failure, reported as a side effect of the clinical use of aminoglycosides, and experimental toxicity apparently follow the neuromuscular block.

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