Modulation of the peritoneal clearance of liposomal cytosine arabinoside by blank liposomes
- 1 July 1987
- journal article
- research article
- Published by Springer Nature in Cancer Chemotherapy and Pharmacology
- Vol. 19 (4) , 307-310
- https://doi.org/10.1007/bf00261478
Abstract
Liposomes containing cytosine arabinoside (ara-C) release drug slowly and can be used to maintain a locally high concentration of ara-C in the peritoneal cavity for intracavitary chemotherapy. However, a significant amount of active drug does reach the systemic circulation and contributes to systemic toxicity. We have devised a novel method of decreasing toxicity and increasing intraperitoneal half-life by pretreatment with “blank” liposomes containing no active drug. This technique has resulted in prolongation of intraperitoneal half-life of the liposomal ara-C from 21 h to 165 h, enabling maintenance of a therapeutic drug concentration even at 11 days after initial injection. One hundred percent cures (60-day survival) were achieved with a single-dose therapy begun 1 day after i. p. implantation of 106 L1210 leukemia cells.This publication has 22 references indexed in Scilit:
- Studies of Methotrexate-Monoclonal Antibody Conjugates for ImmunotherapyJNCI Journal of the National Cancer Institute, 1985
- Intraperitoneal chemotherapy with high-dose cisplatin and cytosine arabinoside for refractory ovarian carcinoma and other malignancies principally involving the peritoneal cavity.Journal of Clinical Oncology, 1985
- Intraperitoneal cytosine arabinoside therapy in ovarian carcinoma.Journal of Clinical Oncology, 1984
- COMPARISON OF LYMPHATIC UPTAKE, METABOLISM, EXCRETION, AND BIODISTRIBUTION OF FREE AND LIPOSOME-ENTRAPPED [C-14]LABELED CYTOSINE BETA-D-ARABINOFURANOSIDE FOLLOWING INTRAPERITONEAL ADMINISTRATION TO RATS1982
- DISTRIBUTION AND METABOLISM OF LIPSOME-ENCAPSULATED AND FREE 1-BETA-D-ARABINOFURANOSYLCYTOSINE (ARA-C) IN DOG AND MOUSE-TISSUES1982
- INTRALYMPHATIC ADMINISTRATION OF LIPOSOME-ENCAPSULATED DRUGS TO MICE - POSSIBILITY FOR SUPPRESSION OF THE GROWTH OF TUMOR-METASTASES IN THE LYMPH-NODES1981
- SELECTIVE DELIVERY OF LIPOSOME-ASSOCIATED CIS-DICHLORODIAMMINEPLATINUM(II)BY HEAT AND ITS INFLUENCE ON TUMOR DRUG UPTAKE AND GROWTH1981
- PHARMACOKINETIC RATIONALE FOR PERITONEAL DRUG ADMINISTRATION IN TREATMENT OF OVARIAN CANCER1978
- Pharmacokinetics of liposome-encapsulated anti-tumor drugsBiochemical Pharmacology, 1978
- On the Enzymatic Determination of Blood GlucoseScandinavian Journal of Clinical and Laboratory Investigation, 1960