Cerebrospinal Fluid pH and Monoamine and Glucolytic Metabolites in Alzheimer's Disease

Publisher Website
Google Scholar
Abstract
Determinations of acid monoamine metabolites, such as homovanillic acid (HVA) and 5-hydroxyindoleacetic acid (5-HIAA), in cerebrospinal fluid (CSF) give valid information on the metabolism of the corresponding amines in the brain tissue (Moiret al., 1970; Roos, 1970). The monoamine metabolites in the CSF are related to age. The concentrations of HVA and 5-HIAA increase with age (Gottfrieset al., 1971). Probenecid blocks the elimination of HVA and 5-HIAA from brain tissue to blood (Neffet al., 1964, 1967; Werdinius, 1966) and from CSF to blood (Guldberget al., 1966; Olsson and Roos, 1968). Probenecid thus normally induces an increase in the concentrations of the acid monoamine metabolites in the CSF, which is related to the turnover of monoamines in the brain tissue.