Prostaglandin endoperoxide synthase contains an EGF-like domain

4 December 1989

journal article
research article
Published by Wiley in FEBS Letters

Vol. 258 (2) , 317-319
https://doi.org/10.1016/0014-5793(89)81683-7

Abstract

Prostaglandin endoperoxide synthase was subjected to the computer-assisted homology search in the protein primary structure database, in order to investigate the regulation mechanism of the expression of prostaglandin endoperoxide synthase. As a result of that, it turned out that prostaglandin endoperoxide synthase shares sequence homology with epidermal growth factor (EGF) in the N-terminal region. The implication of the existence of an EGF-like domain in prostaglandin endoperoxide synthase is discussed.

Keywords

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