Inhibition of Renal Prostaglandin Synthesis and Metabolism by Indomethacin in Rats
- 1 November 1978
- journal article
- research article
- Published by Frontiers Media SA in Experimental Biology and Medicine
- Vol. 159 (2) , 165-170
- https://doi.org/10.3181/00379727-159-40306
Abstract
The effect of indomethacin and other NSAID on renal prostaglandin synthesis and metabolism was studied in nondiuretic rats prepared for acute experimentation. Thirty minutes after the administration of a 2 mg/kg iv dose of indomethacin, the concentration of prostaglandin in renal venous blood as determined by bioassay was reduced 69%. In addition, conversion of radiolabeled arachidonic acid to prostaglandin E2 in vitro by the renal papillae of indomethacin pretreated rats was inhibited 97%.This publication has 6 references indexed in Scilit:
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