Anaesthetic phencyclidine, blocker of the ATP‐sensitive potassium channels
- 17 January 1994
- journal article
- Published by Wiley in FEBS Letters
- Vol. 337 (3) , 277-280
- https://doi.org/10.1016/0014-5793(94)80208-4
Abstract
The double sucrose gap and patch‐clamp studies revealed that phencyclidine blocked the ATP‐sensitive K+ channel in isolated cardiac cells (half‐maximal inhibition at ≈20 μM; Hill coefficient ≈1). 10μM phencyclidine increased the inward Ca2+ current and blocked the outward K+ current in the frog auricle trabeculae. The phencyclidine effects on the frog auricle trabeculae and the isolated cardiac cells proved to be quite reversible.Keywords
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