Activity of amine‐stannous fluoride combination and chlorhexidine against some aerobic and anaerobic oral bacteria

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Abstract
The in vitro susceptibility of 128 bacterial strains was tested to amine fluoride-stannous fluoride (AmF + SnF) and chorhexidine (CHX) solutions. Actinobacillus actinomycetemcomitans, Streptococcus mutans, and Bacteroides intermedius were among the species investigated. The 50% and 90% minimal inhibitory concentrations (MICs) were assessed by an agar dilution method. The MIC ranges for A. actinomycetemcomitans were 2-32 .mu.g/ml for CHX and 0.25-64 .mu.g/ml for AmF + SnF. The respective values for S. mutans were 0.5-8 .mu.g/ml (CHX) and 2-8 .mu.g/ml (AmF + SnF); and 4-8 .mu.g/ml (CHX) and 2-4 .mu.g/ml (AMF + SnF) for B. intermedius. Streptococcus faecalis and Staphylococcus aureus were most resistant of the control strains (MIC 64 .mu.g/ml to CHX and 32 .mu.g/ml to AmF + SnF, respectively). Thus, both solutions tested exerted a definite inhibitory action on the dental plaque pathogens studied.