Tetracycline and Drug-Attributed Rises in Blood Urea Nitrogen

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Abstract
A routine screening analysis of data from a comprehensive drug surveillance program revealed a strong association between tetracycline administration and the development of clinically significant rises in blood urea nitrogen (BUN) levels. This prompted a detailed analysis in which age, sex, admission BUN levels, discharge diagnosis, participating hospital, and severity of illness were controlled. The association was found to be confined to tetracycline recipients who also received diuretics. When the frequency of detected rise in BUN levels in this group of patients was compared with two other groups of diuretic recipients, it was found to be significantly higher (P<.001). It is concluded that tetracycline should be avoided in patients also receiving diuretics, when alternative antibiotics can be substituted.

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