Late‐type allergy to the X‐ray contrast medium Solutrast® (iopamidol)

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Abstract
In the past few years, there have been an increasing number of publications on delayed intolerance reactions, including rashes, following the use of X‐ray contrast media. We report a patient in whom infiltrated erythema of the face and generalized maculopapular rashes occurred on 2 occasions, within 1 day, following the use of the X‐ray contrast medium Solutrast® (iopamidol) for coronary angiography. The allergological investigations for clarification included prick tests and patch tests using a series of contrast media, as well as individual intravenous provocation tests. We found the cause to be a late‐type allergy to the active substance iopamidol contained in the contrast medium Solutrast®. We found a concomitant cross‐reactivity to the contrast media iopromid and iomeprol. All 3 contrast media represent the monomeric, non‐ionic type.