DEMONSTRATION OF EBNA (EPSTEIN-BARR VIRUS NUCLEAR ANTIGEN) ANTIBODIES OF DIFFERENT IMMUNOGLOBULIN CLASSES

  • 1 January 1978
    • journal article
    • research article
    • Vol. 25  (4) , 237-243
Abstract
Anti-EBNA Ig[immunoglobulin]M, a previously unknown antibody [Ab], was detected by the anti-human globulin anti-complement immunofluorescence (ACIF) method in serum samples from acute infectious mononucleosis (IM) of Epstein-Barr virus (EBV) origin. The Ab disappears from the serum during convalescence. It was absent in anti-EBV-positive sera of healthy donors and in serum samples taken from patients with IM caused by cytomegalovirus. The Ab appears simultaneously with anti-EBV IgM and, reaching a lower titer than the latter, its titer curve runs parallel with the anti-EBV IgM curve. Since in acute EBV infections, anti-EBNA IgM always appeared, its presence may serve as additional evidence of the acuteness of EBV infection. In EBV-seropositive healthy subjects, the bulk of Ab belongs to the IgG class; noncp-complement-fixing IgA Ab occur only sporadically.

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