VERSATILE METHOD FOR THE PREPARATION OF OPTICALLY ACTIVE α-HYDROXY ALDEHYDES WITH DESIRED CONFIGURATIONS
- 5 June 1979
- journal article
- research article
- Published by Oxford University Press (OUP) in Chemistry Letters
- Vol. 8 (6) , 705-708
- https://doi.org/10.1246/cl.1979.705
Abstract
A convenient method was established for the asymmetric synthesis of various α-hydroxy aldehydes with high optical yields starting from methoxycarbonyl aminal, prepared from methyl hydroxymethoxyacetate and (S)-2-(anilinomethyl)pyrrolidine. The configurations of α-hydroxy aldehydes are arbitrarily controlled by the order of the introduction of two substituents in the α-hydroxy aldehydes originated from Grignard reagents.Keywords
This publication has 1 reference indexed in Scilit:
- Stereochemie aliphatischer Carbonium‐Ionen, 1. Wasserstoff‐Verschiebung im 1‐Hydroxy‐2‐methyl‐butyl‐SystemEuropean Journal of Inorganic Chemistry, 1971