A Facile and Convenient Synthetic Method forN-β-Trifluoroacetylvinyl Amino Acid Esters, α-Aminoacetophenones and Aminoacetonitriles as Potentially Useful Precursors of Fluorine-Containing Pyrroles
- 1 January 1992
- journal article
- research article
- Published by Georg Thieme Verlag KG in Synthesis
- Vol. 1992 (06) , 533-535
- https://doi.org/10.1055/s-1992-26155
Abstract
N-(4,4,4-Trifluoro-3-oxo-1-butenyl) amino acid esters, α-aminoacetophenones and aminoacetonitriles 3 and 4 are easily obtained in excellent yields by O-N exchange reaction of 4-alkoxy-1,1,1-trifluoro-3-alken-2-ones 1 and 2 with some amino acid esters, α-aminoacetophenone and aminoacetonitrile. Cyclodehydration of some resultant products into fluorine-containing pyrroles is also described.Keywords
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