EARLY ENDOTHELIAL CHANGES IN EXPERIMENTAL PRIMATE ATHEROSCLEROSIS

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  • 1 January 1979
    • journal article
    • research article
    • Vol. 41  (4) , 294-302
Abstract
Aortic tissues of cholesterol-fed African green monkeys were studied by light microscopy and EM. The sampled areas were either grossly normal, or showed minute grayish white translucent or yellowish white intimal elevations. Samples of topographically corresponding areas from animals on normal diet served as controls. By light microscopy, the intimal elevations were either pure fatty dots or a combination of fatty dots and focal intimal edema. The most conspicuous ultrastructural findings in the experimental animals were a marked increase in the number of Weibel-Palade bodies, and figures suggestive of release of their content into the vascular lumen. Invaginations or pseudochannels of varying depth and intracytoplasmic lipid inclusions were observed experimentally. Weibel-Palade bodies may play a role in the initial stages of atherosclerotic lesions and transendothelial transport may take place via transendothelial channels.

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