The effect of clonidine on sevoflurane requirements for anaesthesia and hypnosis
Open Access
- 1 April 1997
- journal article
- clinical trial
- Published by Wiley in Anaesthesia
- Vol. 52 (4) , 377-381
- https://doi.org/10.1111/j.1365-2044.1997.az0083d.x
Abstract
We evaluated the effects of clonidine given orally on sevoflurane requirements for anaesthesia and hypnosis. Patients received either clonidine (5 μg.kg−1) by mouth (n =21) 90 min before surgery or no premedication (n =21) by random allocation. MAC was calculated using repeated tetanic nerve stimulation with end‐tidal sevoflurane concentration increased or decreased by 0.3 vol.% depending on the previous response. MAC awake was calculated according to the response to verbal command. The mean (SD) MAC in the clonidine‐treated patients was 1.53 (0.20)% compared with 1.83 (0.15)% in the control group (p −1 orally administered pre‐operatively reduces sevoflurane requirements for anaesthesia and hypnosis.Keywords
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