Gut-Derived Mesenteric Lymph

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Abstract
IT IS WELL KNOWN that the development of adult respiratory distress syndrome complicates the recovery of patients with severe thermal injury.1 Acute lung injury (lung leak) has also been observed in rats subjected to thermal injury, and thermal injury is associated with a variety of responses that may contribute to lung leak.2,3 For example, damage to the pulmonary vascular endothelium following acute thermal injury has been shown to produce interstitial edema in experimental animals4,5 and severely burned humans.6,7 Although the relationship between thermal injury and pulmonary dysfunction has been recognized for many years, the pathogenesis of microvascular damage to the lung following thermal injury, as well as the burn-induced local microvascular changes, are not well understood. However, since there is a high incidence of respiratory failure (adult respiratory distress syndrome) in patients with large surface area burns in the absence of direct pulmonary injury,8,9 it appears that factors produced outside of the lung itself contribute to pulmonary dysfunction.

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