Pulmonary vascular and renal effects of cromakalim in anaesthetized dogs
- 1 January 1989
- journal article
- Published by Springer Nature in Pflügers Archiv - European Journal of Physiology
- Vol. 414 (S1) , S192-S193
- https://doi.org/10.1007/bf00582302
Abstract
CROM reduced hypoxia-induced pulmonary vasoconstriction and maintained PaO2 with an increase in cardiac output. Low doses of CROM infused into the kidney caused pronounced renal vasodilation, marked natriuresis and a significant increase in cardiac output with minor changes in blood pressure. In addition to its previously described systemic antihypertensive effects, CROM also reduces hypoxia-induced pulmonary hypertension and shows marked renal vasodilation with natriuresis in anaesthetized dogs.Keywords
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