Serum and Rectal Mucosal Copper Status in Acute and Chronic Diarrhea

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Abstract
Serum and rectal mucosal copper content was estimated in children (6-18 months old) with acute diarrhea (group I: n = 50), chronic diarrhea (group II: n = 25), extraintestinal infections (group III: n = 15), and apparently healthy controls (group IV: n = 20). The sex and nutritional status of various groups was comparable. The mean serum copper levels in acute diarrhea and infected control groups were comparable, but singnificantly (p < 0.001) greater in comparison to chronic diarrhea and healthy control groups. The tissue copper in group II was significantly (P < 0.001) lower than other groups, which were comparable. There was a significant negative correlation between serum copper and diarrheal duration (r = -0.615; p < 0.001). Repeat estimation at discharge in 38 patients (25 in group I and 13 in group II) revealed a significant (p < 0.05) reduction in the serum and tissue copper content during this period. Among the 23 infants (16 in group I and 7 in group II) evaluated 2-3 weeks after discharge, there was an increase in copper values of tissue alone (p < 0.05) in group I and both serum and tissue (p > 0.05) in group II. It is concluded that elevation of serum copper in acute diarrhea is a nonspecific response to infection; infants with chronic but not acute diarrhea are copper depleted at presentation; and with the continuation of diarrhea, there is a progressive depletion of copper.