Clearance of 14-3-3 Protein from Cerebrospinal Fluid Heralds the Resolution of Bacterial Meningitis
Open Access
- 1 June 2003
- journal article
- Published by Oxford University Press (OUP) in Clinical Infectious Diseases
- Vol. 36 (11) , 1492-1495
- https://doi.org/10.1086/375066
Abstract
The 14-3-3 protein, a cerebrospinal fluid (CSF) marker of neuronal damage that was recently adopted for the diagnosis of Creutzfeldt-Jakob disease, is also found in the CSF of patients with a variety of neurological disorders. We prospectively studied 12 consecutive patients with purulent bacterial meningitis and found that 14-3-3 protein was detected in all patients at admission to the hospital. All patients who recovered cleared 14-3-3 protein from the CSF before discharge from the hospital (this was the first CSF marker to clear), whereas those who died never cleared the protein.Keywords
This publication has 6 references indexed in Scilit:
- Quantitation of 14-3-3 and neuron-specific enolase proteins in CSF in Creutzfeldt–Jakob diseaseNeurology, 2001
- An enzyme-linked immunosorbent assay to quantify 14-3-3 proteins in the cerebrospinal fluid of suspected Creutzfeldt-Jakob disease patientsAnnals of Neurology, 2000
- Isoform Pattern of 14‐3‐3 Proteins in the Cerebrospinal Fluid of Patients with Creutzfeldt‐Jakob DiseaseJournal of Neurochemistry, 1999
- The 14-3-3 Brain Protein in Cerebrospinal Fluid as a Marker for Transmissible Spongiform EncephalopathiesNew England Journal of Medicine, 1996
- Diagnosis and management of meningitisThe Pediatric Infectious Disease Journal, 1992
- Laboratory diagnosis of bacterial meningitisClinical Microbiology Reviews, 1992