Prognosis for rubeosis iridis following central retinal vein occlusion.

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Abstract
The records of 57 patients with recent central retinal vein occlusion were reviewed to predict the development of rubeosis iridis (RI) and neovascular glaucoma (NVG) from the initial clinical examination, color fundus photographs and fluorescein angiograms. Patients (12, 21%) developed RI and NVG. This complication apparently correlated most significantly with clinical and fluoroangiographic evidence of severe retinal ischemia. The correlation between RI and other findings was as follows: widespread capillary occlusion (86% developed RI); absent perifoveal network (80%); 10 or more cotton-wool spots (75%); A-V arterio-venous transit time of greater than 20 s (75%); severe large vessel leakage (31%); and severe retinal edema (60%). Correlation of RI was less significant with poor visual acuity and with associated systemic diseases. Factors of no statistical prognostic value included the patient''s age, history or evidence of pre-existing open-angle glaucoma, degree of fundus hemorrhage, capillary dilatation, disc edema, disc capillary dilatation and leakage, leakage of small vessels in the posterior pole and development of disc collateral vessels. Using Multivariate linear discriminant analysis of the variables best correlated with the development of RI a linear equation was derived predicting 91% of all patients studied who had central retinal vein occlusion and developed rubeosis iridis.