THE EFFECT OF FUROSEMIDE, A NEW DIURETIC AGENT, ON RENAL CONCENTRATING AND DILUTING MECHANISMS

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Abstract
The effect of a new diuretic, Furosemide, has been studied in normal subjects undergoing both osmotic and water diuresis. A marked increase in the excretion of sodium and water was observed, the latter amounting to 30% of the glomerular filtrate. In the hydropenic subjects the drug virtually abolished negative free water clearance, which indicates that the site of action is in the ascending limb of Henle's loop. In the water-loaded subjects, free water clearance was decreased but not abolished, which suggests that urinary dilution distal to the ascending limb of Henle's loop is not significantly impaired by the diuretic.

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