Cytotoxic Alkaloids from Blue-Green Algae: A Total Synthesis of (-)-Didehydromirabazole A
- 1 January 1992
- journal article
- letter
- Published by Georg Thieme Verlag KG in Synlett
- Vol. 1992 (06) , 533-534
- https://doi.org/10.1055/s-1992-21406
Abstract
A concise total synthesis of the thiazole-thiazoline based metabolite (-)-didehydromirabazole A (2), a cytotoxic alkaloid isolated recently from the blue-green alga Scytonema mirabile, is described which uses sequential cyclocondensation reactions with methyl (R)-2-methylcysteine hydrochloride (5) as key steps, viz 6 → 7 and 10 → 11.Keywords
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