Induction of Persistent Estrus by Electrolytic Lesions Placed Neonatally in the Hypothalamus of the Female Rat

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Abstract
Electrolytic lesions were placed in the hypothalamus of 2-day-old female rats. Destruction of the mediobasal part of the preoptic area resulted in persistent vaginal estrus starting on the day of vaginal opening, while lesions placed laterally in the preoptic-anterior hypothalamic area did not interfere with normal cycles. The mediobasal hypothalamus is apparently capable of undergoing maturation without any postnatal influence from at least the mediobasal part of the anterior hypothalamus. Destruction of the anterior wall of the 3rd ventricle caused persistent or prolonged vaginal estrus preceded by normal cycles. The relationship between the loci of lesions and occurrence of sexual cyclicity was discussed.

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