Autologous transplantation of CD133 selected hematopoietic progenitor cells in a pediatric patient with relapsed leukemia

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Abstract
A pediatric patient with very early meningeal relapse of his CD34+ CD133− pre-B-ALL was transplanted with 2.5 × 106/kg CD133 selected autologous progenitor cells. Enrichment of CD133+ cells resulted in a purity of 92.3 ± 3.5% CD133+. Hematopoietic engraftment with >1.0 × 109/l neutrophils and >50 × 109/l platelets was reached within 13 and 24 days, respectively. At a follow-up of 11½ months after autologous transplantation, the patient is in complete remission. To our knowledge, the successful transplantation with a CD133 selected graft is the first one to be reported worldwide. CD133 selected cells may serve as an alternative in the case of CD34+ malignancy.