GIANT MITOCHONDRIA IN HEPATOCYTES - DIAGNOSTIC HINT FOR ALCOHOLIC LIVER-DISEASE

  • 1 January 1977
    • journal article
    • research article
    • Vol. 73  (6) , 1383-1387
Abstract
Coded liver biopsy specimens [165] were studied by light microscopy to evaluate the occurrence and diagnostic significance of giant mitochondria, which were identified as periodic acid-Schiff-negative globular hyaline cytoplasmic inclusions of regular outline, clearly distinguishable from Mallory bodies. In 4 cases, EM confirmed that these globules were enlarged mitochondria. The incidence of giant mitochondria was significantly higher in patients with high alcohol consumption (72%) than in those with low or no alcohol intake (10%). Their presence was related to the amount of daily ethanol consumption and to the shortness of abstinence before the biopsy. It was independent of other changes in the liver and was detected with similar frequency in biopsies showing different alcoholic liver disease. Giant mitochondria may be detected by light microscopy in a high proportion of alcoholics and rarely in nonalcoholic liver diseases. Although less specific, they are much more frequent than Mallory bodies. Consequently they should be considered as a diagnostic hint of recent and heavy alcoholism.

This publication has 0 references indexed in Scilit: