The Production of Granulocyte Colony-Stimulating Factor and Interleukin 6 by Human Bone arrow Stromal Cells in Aplastic Anemia.

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Abstract
TANI, K., OZAWA, K., OGURA, H., TAKAHASHI, S., TAKAHASHI, K., TSURUTA, T., OKANO, A., AKIYAMA, Y., YOSHIKUBO, T., SHIMANE, M. and ASANO, S. The Production of Granulocyte Colony-Stimulating Factor and Interleukin 6 by Human Bone Marrow Stromal Cells in Aplastic Anemia. Tohoku J. Exp. ed., 1993, 169 (4), 325-334-Stromal cells are known to produce granulocyte colony- stimulating factor (G-CSF) and interleukin 6 (IL-6). To assess the function of bone marrow Stromal cells in the pathological state, we studied their in vitro ability to produce G-CSF and IL-6 in 9 patients with aplastic anemia and 5 normal volunteers, using an enzyme immunoassay method. Constitutive production of IL-6, but not G-CSF, was detected in almost all cases. Interestingly, the inducible production of G-CSF and IL-6 by stromal cells after stimulation with Interleukin-1 and/or lipopolysaccharides was severely depressed in 3 patients with aplastic anemia. Our results may reflect poor hematopoietic activity in the bone marrow in some cases of aplastic anemia.-bone marrow stromal cells; granulocyte colony-stimulating factor; interleukin-6; aplastic anemia

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