Book Review: Iron and Parkinson’s Disease
- 1 February 2002
- journal article
- review article
- Published by SAGE Publications in The Neuroscientist
- Vol. 8 (1) , 22-32
- https://doi.org/10.1177/107385840200800107
Abstract
Multiple studies implicate iron in the pathophysiology of Parkinson’s disease (PD). In the brains of patients with PD, iron levels are elevated and the levels of iron-binding proteins are abnormal. Iron has been suspected to contribute to PD because Fe(II) is known to promote oxidative damage. Recent studies suggest that an additional mechanism by which iron might contribute to PD is by inducing aggregation of the α-synuclein, which is a protein that accumulates in Lewy bodies in PD.Keywords
This publication has 54 references indexed in Scilit:
- Co-association of parkin and α-synucleinNeuroReport, 2001
- Chronic systemic pesticide exposure reproduces features of Parkinson's diseaseNature Neuroscience, 2000
- Parkin is metabolized by the ubiquitin/proteosome systemNeuroReport, 2000
- Mice Lacking α-Synuclein Display Functional Deficits in the Nigrostriatal Dopamine SystemNeuron, 2000
- Multiple System Atrophy: A Sporadic SynucleinopathyBrain Pathology, 1999
- Phosphorus magnetic resonance spectroscopy in multiple system atrophy and Parkinson's diseaseMovement Disorders, 1999
- Accelerated in vitro fibril formation by a mutant α-synuclein linked to early-onset Parkinson diseaseNature Medicine, 1998
- Formation of Neuronal Intranuclear Inclusions Underlies the Neurological Dysfunction in Mice Transgenic for the HD MutationCell, 1997
- The CYP2D6B allele is associated with a milder synaptic pathology in Alzheimer's diseaseAnnals of Neurology, 1995
- A Quantitative Analysis of Isoferritins in Select Regions of Aged, Parkinsonian, and Alzheimer's Diseased BrainsJournal of Neurochemistry, 1995